Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-056-1 | CAS number: 2043-57-4
Endpoint summary
Administrative data
Description of key information
There is no study on skin and eye irritation available with the test item 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane itself. Existing data from a skin as well as an eye irritation study with the surrogate substance 2-Perfluoralkylethyljodide (CAS no. 85995-91-1) are taken for the evaluation because the main compound of this substance is the 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluoro-8-iodooctane with about 42 % . Due to workplace safety aspects the read across was chosen to demonstrate that there is low potential of irritany of this class of substances.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
The acute dermal irritating potential of the test item was investigated in three New Zealand White rabbits. 500 mg of the undiluted test substance was applied to the shaved skin and covered semi occlusive for a 4 hour exposure. Observation periods were approximately 1h, 24 h, 48 h and 72h after removing of the patch. The overall irritation score was determined to be 0.22. Based on the results of the test substance has not to be classified.
Eye irritation:
The acute eye irritating potential of the test item was investigated in three New Zealand White rabbits. The test item was applied by instillation of 100 mg of the undiluted test substance into the left eye of each of three rabbits. Irritation effects were scored approximately 1h, 24 h, 48 h and 72h after test item instillation. 24 hours after instillation the eyes were rinsed with warm physiological saline solution.
The mean score was calculated across 3 scoring times (i.e. 24h, 48h and 72h after instillation) for each animal. The individual mean scores for corneal opacity and changes of the iris were 0.00 for all three animals. The individual mean scores for the conjunctivae were 0.33, 0.00 and 0.66 for reddening and 0.00 for chemosis for all three animals. Based on the results of this test the test substance has not to be classified.Justification for classification or non-classification
According to the CLP regulation and based on the results obtained in the above mentioned OECD 404 and 405 studies the surrogate substance has not to be classified. The same applies for the substance under evaluation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
