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EC number: 407-560-9
CAS number: 107934-68-9
The acute inhalation toxicity of the test
substance was investigated according to OECD TG 436 and GLP principles.
The substance was administered as an aerosol by nose-only inhalation for
4 hours to one group of three male and three female rats. Animals were
subjected to daily observations and determination of body weights on
Days 1, 2, 4, 8 and 15. Macroscopic examination was performed after
The actual time weighted mean concentration
was 3 ± 0.1 mg/L. The nominal concentration (amount of test substance
used divided by the volume of pressurized air used) was 44 mg/L. The
generation efficiency (ratio of actual and nominal concentration) was
8%. The concentration measurements (n=15) equally distributed over time
showed that it was difficult to maintain a stable level at this
technically maximum attainable concentration. The generation was
interrupted in order to remove test substance deposits from the system
at four occasions with a total interruption time of approximately 30
minutes. The generation time was elongated (total generation time 253
minutes) to compensate for these interruptions, resulting in an actual
exposure time of at least 227 minutes. Since the interruptions and
variations in concentration were taken into account by calculation a
time weighted mean concentration, it was considered that the results of
this study are representative for a single exposure of 3 mg/L for 4
hours. This was the technically maximum attainable concentration.
MMAOD was measured twice, 3.2 µm (GSD 2.1)
and 3.9 µm (GSD 2.3).
No mortality occurred and no clinical signs
were noted following the exposure. Rapid breathing was seen during
exposure. Overall body weight gain in males was considered normal and
after an initial body weight loss in females the first week
post-exposure, two out of the three females regained the weight during
the second week. No abnormalities were found at macroscopic post mortem
The 4h-LC50 of the test material in rats was
established to exceed the maximum obtainable concentration of 3 mg/L
Based on these results
4,4’-(9H-fluoren-9-ylidene)bis(2-chloroaniline) does not have to be
classified and has no obligatory labelling requirement for acute
inhalation toxicity according to the Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) of the United Nations
(2011) (including all amendments) and Regulation (EC) No 1272/2008 on
classification, labelling and packaging of substances and mixtures
(including all amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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