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Description of key information

Data on toxicokinetics of the submission substance are not available. Default values based on physico-chemical information are therefore used for the estimation of the kinetic profile. Based on the molecular mass of 187 and a log Kow of 0 a default value of 100% is used for oral as well as dermal absorption. However, respiratory absorption is considered to be negligible because the material is a liquid with a very low vapour pressure (0.002 Pa) and a good water miscibility. 

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100

Additional information

The toxicokinetic profile of a substance comprises its absorption into the body, its distribution in the body, its metabolism in the body and its excretion from the body. Experimental data on toxicokinetics for the test item are not available. However, taking into account the physicochemical properties of the submission substance, qualitative estimates for these aspects may be deduced for the submission substance.

A prerequisite for a relevant absorption is that the substance can be dissolved in either aqueous (e.g., gastrointestinal fluid, blood plasma, sweat) or lipophilic (e.g., lipoproteins, lipid membranes, triglycerides) media or in both. The submission substance is fully miscible with both, water and n-octanol at any ratio leading to a log Kow of 0. This relative solubility is favourable for absorption via the gastrointestinal tract following oral exposure as well as regarding dermal absorption. In the absence of substance specific data and according to ECHA Guidance R.7c, a default value of 100% for oral and skin absorption therefore apply for risk characterization purposes. Due to this physico-chemical profile, excretion of the submission substance can be expected and a bioaccumulation potential can most probably be excluded. The likelihood for inhalation exposure is low due to the very low vapour pressure of the test item. Additionally, since the submission substance is not a solid, formation of inhalable/respirable particles and thus absorption via the inhalation route is unlikely.