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EC number: 224-809-5
CAS number: 4500-29-2
Data on toxicokinetics of the submission substance are not available. Default values based on physico-chemical information are therefore used for the estimation of the kinetic profile. Based on the molecular mass of 187 and a log Kow of 0 a default value of 100% is used for oral as well as dermal absorption. However, respiratory absorption is considered to be negligible because the material is a liquid with a very low vapour pressure (0.002 Pa) and a good water miscibility.
toxicokinetic profile of a substance comprises its absorption into the
body, its distribution in the body, its metabolism in the body and its
excretion from the body. Experimental data on toxicokinetics for the
test item are not available. However, taking into account the
physicochemical properties of the submission substance, qualitative
estimates for these aspects may be deduced for the submission substance.
for a relevant absorption is that the substance can be dissolved in
either aqueous (e.g., gastrointestinal fluid, blood plasma, sweat) or
lipophilic (e.g., lipoproteins, lipid membranes, triglycerides) media or
in both. The submission substance is fully miscible with both, water and
n-octanol at any ratio leading to a log Kow of 0. This relative
solubility is favourable for absorption via the gastrointestinal tract
following oral exposure as well as regarding dermal absorption. In the
absence of substance specific data and according to ECHA Guidance R.7c,
a default value of 100% for oral and skin absorption therefore apply for
risk characterization purposes. Due to this physico-chemical profile,
excretion of the submission substance can be expected and a
bioaccumulation potential can most probably be excluded. The likelihood
for inhalation exposure is low due to the very low vapour pressure of the
test item. Additionally, since the submission substance is not a solid,
formation of inhalable/respirable particles and thus absorption via the
inhalation route is unlikely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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