Registration Dossier
Registration Dossier
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EC number: 200-274-3 | CAS number: 56-45-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental test results for the substance are available.
Results form other proteinogenic amino acids (L-valine, D/L-methionine, L-arginine) clearly indicate that these substances show no/very low toxicty to fish even if applied in very high concentrations (>1 g/l).
The LC50 for fish (Pimephales promelas) to L-serine was estimatied to be 120 g/l by trend analyis using the OECD QSAR Toolbox (Version 3.0; data base version: 3.4.2/3.1.2). Although the substance was not in the applicability domain of the prediction due to the very low logKow of the substance the results clearly indicate a very low toxicity / absence of toxicity to fish.
This very low fish toxicity was further confirmed by the result of a QSAR (EcoSAR, EpiSuite) that predicted an 96h-LC50 of 354 g/L for L-serine (class Aliphatic Amines-acid).
Very low aquatic toxicty was already shown for algae and daphnia. A weight of evidence approach with data from Read-across substances (other proteinogenic amino acids) and QSARs convincingly prove absence of toxicity /low toxicity to fish. Available data are sufficient for classification and risk characterisation. Therefore it is justified not to perform further testing on vertebrates (fish) with L-serine for animal wellfare reasons.
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