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EC number: 205-031-5
CAS number: 131-57-7
The test material was tested for its potential to induce reverse
mutation in bacteria using Salmonella typhimurium TA 98, TA 100, TA
1535, TA 1537 and TA 1538 and Escherichia coli WP2 and WP2 uvrA as
tester strains. The test item was investigated at concentrations between
100 and 1250 µg/plate in the presence and absence of a metabolic
activation system (S9 mix derived from male rats pre-treated with
Aroclor 1254) using the plate incorporation technique. Two experiments
were performed. Negative solvent control and appropriate positive
controls were carried along. The design of the study meets the
requirements of test guideline OECD 471.
In a preliminary test using concentrations between 5 and 10000 µg/plate,
toxicity was observed at concentrations >1250 µg/plate.
The test material was dissolved in DMSO and tested at concentrations
ranging from 100 to 1250 µg/plate.
The test material did not show any mutagenic activity up to the highest
concentration tested in the presence and absence of metabolic activation
where the substances used as positive controls led to a clear increase
in revertant colonies in the expected range.
Based on the results of this study, the test material is considered to
be not mutagenic in this bacterial mutagenicity assay.
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