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EC number: 701-362-9
CAS number: -
The study was initiated with one rabbit (animal no. 1889). Since no
marked eye irritation was seen in this animal another two rabbits were
included in the study with time difference.
1: Scores for ocular lesions
Weight per kg
Individual mean score*
1889 / 2.9
Cornea opacity, degree
Cornea opacity, area
1895 / 2.8
1896 / 2.8
- Reading after instillation of fluorescein
Only the scores from the readings after 24, 48 and 72 h are included in
the calculation of the individual mean scores
an eye irritation study conducted according to the OECD Guideline 405
and in compliance with GLP, 3 healthy female albino rabbits of the stock
Chbb:HM (SPF) – Littlerussian were exposed to 0.1 mL of Bisphenol A
ethoxylate diacrylate in one eye, while the contralateral eye remained
untreated and served as control. The eyelids were then gently held
together for one second before releasing. The eyes were examined 1 h and
24 h after instillation. After
the first 24 h reading fluorescein was instilled and eyes were examined
for ocular lesions. After rinsing with 20 mL 0.9% sodium chloride
solution, the eyes were examined again using UV -light to detect
possible corneal damage. The eyes
were also examined 48 and 72 h after the treatment. Draize
(1977) scoring system was followed to grade the ocular reactions.
hour after application of the test article, animals showed conjunctival
redness, chemosis and discharge different from normal. All
the eyes were normal one day after instillation. Mean individual scores
at 24, 48 and 72 h after exposure for the 3 animals were 0, 0, 0 for
cornea score; 0, 0, 0 for iris score; 0, 0, 0 for conjunctivae score and
0, 0, 0 for chemosis score. In this study, Bisphenol A ethoxylate
diacrylate is not an eye irritant on female rabbits.
the test conditions, Bisphenol A ethoxylate diacrylate is not classified
as irritating to eyes.
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