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EC number: 701-362-9
CAS number: -
No experimental toxicokinetic study is available on Ethoxylated bisphenol A diacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.Based on the toxicological data and the physicochemical properties, absorption of the substance is expected by oral route at the high doses, but a low or no absorption is expected by dermal route and by inhalation.
No experimental toxicokinetic study is available on Ethoxylated
bisphenol A diacrylate. However, as per REACH guidance document R7.C
(May 2008), information on absorption, distribution, metabolism and
excretion may be deduced from the physicochemical properties, including:
-Molecular weight: [424 -556]
g/mol for 88% of the reaction products
-Water solubility: 0.425 mg/L (20°C)
-Partition coefficient Log Kow: 3.66 -4.16
-Vapour pressure: 0.335 10^-6 Pa
The value of log Kow (near to 3 and 4) and the low water
solubility are in the range suggestive of low absorption from the
gastro-intestinal tract subsequent to oral ingestion. Indeed the
absorption of highly lipophilic substances may be limited by the
inability of such substances to dissolve into GI fluids
This assumption of a low oral absorption is confirmed in the acute
toxicity study: no systemic effect or mortality was observed in rats
treated at 2000 mg/kg bw. However clinical signs and a minimal liver
toxicity were observed in the repeated toxicity study at the highest
dose (1000 mg/kg/day). Indeed, Ethoxylated bisphenol A diacrylate
seems to be absorption by oral route at the high doses.
With low water solubility, a high value of log Kow and a molecular
mass near to 500 g/mol, dermal absorption is anticipated to be low.
Moreover, the acrylates are known to bind to skin components, and this
binding decreases their dermal absorption. This assumption of a low
dermal absorption is confirmed in the dermal acute toxicity study, where
no systemic effect or mortality was observed in rats treated at 2000
mg/kg bw. Moreover, Ethoxylated bisphenol A diacrylate showed no
allergic reaction in the LLNA.
Based on the molecular mass near to 500 and a log Kow near to 3
-4, a dermal absorption can be estimated to be 50%.
Based on the very low value of the vapour pressure, Ethoxylated
bisphenol A diacrylate is not a volatile substance. With the low water
solubility, no absorption by inhalation is expected for this substance.
DISTRIBUTION and METABOLISM
The molecule is lipophilic (log Kow near to 3 and 4), it is likely
to distribute into cells and the intracellular concentration may be
higher than extracellular concentration particularly in fatty tissues.
This assumption is confirmed by the changes shown in the repeated dose
toxicity studies following oral application: increase of blood
cholesterol levels at 1000 mg/kg/day, which were observed in presence of
non-adverse increase of mean liver weight and liver microscopic findings
No specific data is available on the metabolism of Ethoxylated
bisphenol A diacrylate.
Due to the low water solubility and a moderate molecular mass
(between 200 and 1000 g/mol), the excretion of Ethoxylated bisphenol A
diacrylate in the urines is not expected. An excretion via bile and
faeces is possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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