Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acute aquatic toxocity has been obtained by read-across method from category members using the OECD Toolbox v.3.1.

Data source

Reference
Reference Type:
other: software
Title:
QSAR Toolbox 3.1.0.21
Author:
OECD
Year:
2013
Bibliographic source:
http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:
Read-across from category members
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent

Test organisms

Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)

Study design

Test type:
static

Results and discussion

Effect concentrations
Dose descriptor:
EC50
Effect conc.:
27.1 mg/L
Remarks on result:
other: Calculated by OECD Toolbox v.3.1

Any other information on results incl. tables

Toxicity of the target chemical (27.1 mg/L) is predicted from category members using read-across based on 4 values within the range 3.75 - 160 mg/L from 4 nearest neighbours compared by prediction descriptors. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical.

Read-across from category members.

The target chemical FALLS within applicability domain.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
A EC50 of 27.1 mg/L Pseudokirchnerella subcapitata has been predicted.