Registration Dossier
Registration Dossier
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EC number: 278-593-2 | CAS number: 77017-20-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acute aquatic toxocity has been obtained by read-across method from category members using the OECD Toolbox v.3.1.
Data source
Reference
- Reference Type:
- other: software
- Title:
- QSAR Toolbox 3.1.0.21
- Author:
- OECD
- Year:
- 2 013
- Bibliographic source:
- http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm
Materials and methods
- Principles of method if other than guideline:
- Read-across from category members
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Androst-4-ene-3,17-dione
- EC Number:
- 200-554-5
- EC Name:
- Androst-4-ene-3,17-dione
- Cas Number:
- 63-05-8
- IUPAC Name:
- androst-4-ene-3,17-dione
- Reference substance name:
- Betamethasone
- EC Number:
- 206-825-4
- EC Name:
- Betamethasone
- Cas Number:
- 378-44-9
- IUPAC Name:
- 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
- Reference substance name:
- Prednisolone
- EC Number:
- 200-021-7
- EC Name:
- Prednisolone
- Cas Number:
- 50-24-8
- IUPAC Name:
- 11,17,21-trihydroxypregna-1,4-diene-3,20-dione
- Reference substance name:
- 5571-36-8
- EC Number:
- 611-306-4
- Cas Number:
- 5571-36-8
- IUPAC Name:
- 5571-36-8
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
Results and discussion
Effect concentrations
- Dose descriptor:
- EC50
- Effect conc.:
- 27.1 mg/L
- Remarks on result:
- other: Calculated by OECD Toolbox v.3.1
Any other information on results incl. tables
Toxicity of the target chemical (27.1 mg/L) is predicted from category members using read-across based on 4 values within the range 3.75 - 160 mg/L from 4 nearest neighbours compared by prediction descriptors. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical.
Read-across from category members.
The target chemical FALLS within applicability domain.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A EC50 of 27.1 mg/L Pseudokirchnerella subcapitata has been predicted.
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