N,N-dimethylaniline

Endpoint summary

Additional information

N,N-dimethylaniline has a harmonized classification of Aquatic chronic category 2. Thus, though some of the below mentioned results support a lower category of aquatic classification, in the chemical safety assessment, the harmonized classification categories have been considered.

Short-term toxicity to fish:

Weight of evidence studies were reviewed for short-term toxicity to fish from reliable sources having Klimish 4.

The summary of the results are presented below:

Sr. No.	Endpoint	Duration	Value	Species	Source
1.	LC50	48 hr	33 mg/L	Oryzias latipes	The Journal of Toxicological Sciences
2.	EC50	48 hr	56 mg/L	Carassius auratus	Journal of Hygienic Chemistry/Eisei Kagaku
3.	LC50	96 hr	78.2 mg/L	Pimephales promelas	Superior, WI:Center Lake Superior Environmental Studies Univ.Wisconsin Superior
4.	EC50	96 hr	75.2 mg/L	Pimephales promelas	Superior, WI:Center Lake Superior Environmental Studies Univ.Wisconsin Superior

As per the CLP criteria, the available values will result inclassification of N,N-dimethylaniline in Aquatic Chronic Category 3.

Long-term toxicity to fish:

The long term lethal concentration (LC0) value of N,N-dimethylaniline in fish [Cyprinus carpio] in a 5.79 day study was found to be between 34-101 mg/L.

Short-term toxicity to aquatic invertebrates:

Based on studies of target substanceN,N-dimethylanilinereviewed for Short-term toxicity to aquatic invertebrate from reliable sources having Klimisch rating 2 considering weight of evidence approach 

The summary of the results are presented below

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	EC50	13.7 mg/L	Intoxication and mobility	48 hrs	Daphnia magna	publication
2	EC50	5.8 mg/L	Intoxication and mobility	24 hrs	Daphnia magna	Study report
3	EC50	2.3 mg/l	Intoxication and mobility	48 hrs	Daphnia magna	Study report

 

Based on results summarized in above table for the target substanceN,N-dimethylanilinethe effective concentration (EC50) value varies from 2.3 to 13.7 mg/L. This value indicates that the chemical will exhibit short term toxicity to aquatic invertebrates. As per the CLP criteria, this classification amounts to Aquatic Chronic Category 3.

Long-term toxicity to aquatic invertebrates:

According to column 1, annex IX, Long term toxicity to aquatic invertebrate can be considered for waiver, since short term toxicity information has been provided in section 6.1.3 of this dossier.

Toxicity to aquatic algae and cyanobacteria:

Based on studies of target substanceN,N-dimethylanilinereviewed for Short-term toxicity to aquatic algae from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach 

The summary of the results are presented below

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1.	EC50	22 mg/l	Growth rate	72 hrs	Chlorella pyrenoidosa	Publication
2.	LOEC and NOEC	22 and 14 mg/l	Growth rate	72 hrs	Chlorella pyrenoidosa	Publication

 

Based on results summarized in above table for the target substanceN,N-dimethylanilinethe effective concentration (EC50) value is 22 mg/l and the LOEC and NOEC values are reported to be 22 and 14 mg/l.The test substance is non toxic to algae below the above mentioned doses.

Toxicity to microorganisms:

Based on studies of target substanceN,N-dimethylanilinereviewed for toxicity to microorganism from reliable sources having Klimisch rating 2 considering weight of evidence approach 

The summary of the results are presented below

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1.	EC50	110 mg/l	growth inhibition	24 hrs	Tetrahymena pyriformis	Publication
2.	EC50	59.4882 mg/l	growth inhibition	46 hrs	Tetrahymena pyriformis	Publication
3.	EC50	13.6 mg/L	reduction in light emission	30 min	Photobacterium phosphoreum	Publication

 

Based on the results summarized in above table for the target substanceN,N-dimethylanilinethe endpoint values of microorganism (Tetrahymena pyriformis and Photobacterium phosphoreum), varies from 13.6 mg/L to 110 mg/l.