Registration Dossier
Registration Dossier
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EC number: 252-043-1 | CAS number: 34454-97-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The serum half life for the test article was 17 hours. The total fluorine elimination rates were similar in both serum and liver for animals treated with the test article.
Key value for chemical safety assessment
Additional information
Male Sprague-Dawley rats received a single 30 mg/kg dose of the test compound in propylene glycol by oral gavage at a volume of 5 mL/kg body weight. The vehicle control group rats received a single dose of ethylene glycol at a volume of 5 mL/kg. Necropsies were performed at 4 hours, 28 hours and 100 hours post dose. At necropsy there were no significant differences in body weight or gross macroscopic observations between any of the treatment groups and the control group. Animals had average total fluorine concentrations in serum of 10.8 ppm four hours post-dose, 23.1 ppm 28 hours post dose, and 1.0 ppm 100 hours post dose. The average liver total fluorine concentrations were 14.1, 18.3, and 2.2 ppm after 4, 28, and 100 hours post dose, respectively.
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