Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-813-2 | CAS number: 74-83-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- As this is an academic piece of work, no specific guidelines were required
- GLP compliance:
- no
- Remarks:
- No, the study is an academic piece of work for which GLP was not required
- Type of assay:
- other: in vitro Fluctuation test, (Klebsiella pneumoniae ur- pro-), the Ames assay (Salmonella typhimurium strains TA98 and TA100) and the Mouse lymphoma cell assay (L5178Y (TK+/-) mouse lymphoma cells) but not in the DNA-repair assay (Primary rat-liver cells).
Test material
- Reference substance name:
- Bromomethane
- EC Number:
- 200-813-2
- EC Name:
- Bromomethane
- Cas Number:
- 74-83-9
- Molecular formula:
- CH3Br
- IUPAC Name:
- bromomethane
- Details on test material:
- Methyl Bromide; batch no. not documented; Purity: 99%
Constituent 1
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 98, TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- ambiguous
- Remarks:
- S. typhimurium TA 98: Negative; TA 100: Positive.
Any other information on results incl. tables
Applicant's summary and conclusion
- Conclusions:
- Methyl Bromide was mutagenic in vitro in the Fluctuation test, (Klebsiella pneumoniae ur- pro-), the Ames assay (Salmonella typhimurium strains TA98 and TA100) and the Mouse lymphoma cell assay (L5178Y (TK+/-) mouse lymphoma cells) but not in the DNA-repair assay (Primary rat-liver cells). The results indicate a relatively low mutagenic efficiency of the compound.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
