Registration Dossier
Registration Dossier
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EC number: 428-320-1 | CAS number: 71308-16-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In a 28-day oral study (gavage) in rats, the animals of the mid and high dose group (100 and 316 mg / kg Body weight) exhibited liver and spleen weight changes with histological changes, indicating the uptake of a toxicologically relevant amount of the test item.
All findings were found to be reversible after a recovery period of 6 weeks.
This indicates an adaptive effect of the liver to the treatment, most probably due to increased activation of the metabolic enzyme system. Theoretically, metabolism would proceed by oxidation of the alkyl side chain, hydroxylation at the quinone ring system and the reduction of quinone to the corresponding hydroquinone phase II conjugates, and thus excreted in the urine or faeces.
The substance is practically insoluble in water. Skin absorption is expected to be negligble due to the low water solubility and high molecular weight (>250). The endpoint of concern for the skin is sensitisation, therefore exposure is to be avoided.
Key value for chemical safety assessment
Additional information
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