Registration Dossier

Administrative data

First-aid measures

Emergency measure - Inhalation: Bring affected person to fresh air and keep in resting
position; if person feels unwell, seek medical advice.
Emergency measure - Eyes: Wash inmediately with plenty of water with open eye at least
for 15 min;seek medical advice immediately.
Emergency measure - Skin: Remove contaminated clothes; wash with plenty water and
soap; seek medical advice, if irritation develops.
Emergency measure - Ingestion: Give affected person 3-4-glasses of water to drink; do not
induce vomiting; if vomitting occures, give water again;
seek medical advice immediately

Fire-fighting measures

Recommended extinguishing agent: carbon dioxide or dry powder for surrounding fire and
materials

Product arising from burning: carbon dioxide, water

Product determined by test: N

Protective equipment: self-contained respiration protection and the common
protection measures for fires with chemicals.

Accidental release measures

Emergency measures in case of spillage: Wear approved respirator, eye protection, personal
protective coverings and gloves. Use HEPA filtered vacuum or
wet sweeping to clean up spillage. Avoid dust. Place
spillage in appropiate container for waste disposal. Wash
contaminated clothing for waste disposal. Wash contaminated
clothing before reuse. Ventilate area and wash spill site.

Handling and storage

Handling: Prevent the formation of dust.


Use with adequate dust control and local ventilation.


Avoid contact with eyes, skin and clothing.


Workers should wear gloves and anti-dust masques.


Shower body after handling.


Wear fresh clothes daily.


No special precautions against fire and explosion is require
d.

Storage: Store at room temperature, in original container, protect
from heat and direct sunlight.

Packaging of the substance and or preparation: The substance is packed in steel containers Buck docking
system.

Transport information

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Marine transport (IMDG)

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Air transport ICAO/IATA

Remarks
Transport code: 1544, Solid Alkaloid
Transport: It is clasified as a toxic good and packaging Group I.

Labelling 6.1, II ADR
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Exposure controls / personal protection

Stability and reactivity

Chemical reaction with water: CAMPTOTHECIN is not reactive with water.

Dust explosion: none

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Industry - Possibility of neutralisation: During semisynthetic or total synthetic chemistry programs
the particular importance of the lactone ring and the 20
(S)-configuration for activity was recognized. With an
alkali solution ( 5% Sodium hydroxide solution ) the
Camptothecin lactone ring is easily hydrolized.

Industry - Possibility of destruction: controlled discharge: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Industry - Possibility of destruction - incineration: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Industry - Possibility of destruction - water purification: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Industry - Possibility of destruction - other: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Public at large - Possibility of recovery/recycling: Does not apply due to the fact that CAMPTOTHECIN is used by
industry in closed systems only.

Public at large - Possibility of neutralisation: With an alkali solution ( 5 % Sodium hydroxide solution )

Public at large - Possibility of destruction: controlled discharge: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Public at large - Possibility of destruction - incineration: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Public at large - Possibility of destruction - water purification: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.

Public at large - Possibility of destruction - others: Does not apply due to the fact that CAMPTOTHECIN is an
intermediate for a chemical reaction.