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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no

Test material

Test animals / tissue source

Species:
rabbit
Strain:
other:

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other:
Score:
3
Max. score:
3
Reversibility:
fully reversible within:
Remarks on result:
other:
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other:
Score:
2.67
Max. score:
3
Reversibility:
fully reversible within:
Remarks on result:
other:
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other:
Score:
3
Max. score:
3
Reversibility:
fully reversible within:
Remarks on result:
other:
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other:
Score:
1.67
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other:
Score:
0.67
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other:
Score:
2.67
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other:
Score:
1
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other:
Score:
1.33
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other:
Score:
1
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other:
Score:
1.33
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other:
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other:
Score:
0.67
Max. score:
2
Reversibility:
fully reversible within:
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other:
Score:
1
Max. score:
2
Reversibility:
fully reversible within:
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other:
Score:
0.67
Max. score:
2
Reversibility:
fully reversible within:

Applicant's summary and conclusion