Alicyclediyldimethanol and [(hydroxymethyl)alicyclic]methyl (hydroxymethyl)alicyclecarboxylate and [oxybis(methylenealicyclediyl)]dimethanol

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)

GLP compliance:

yes

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Details on test organisms:

Green algae

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

72 h

Test temperature:

21.1 ± 0.0ºC

pH:

pH 7.75-8.96

Nominal and measured concentrations:

Solubility test: 100 mg/L (initial conc.)
Range-finding test: 0.1, 1, 10, 100 mg/L (nominal conc.)
Definitive test: 0, 6.25, 12.5, 25, 50, 100 mg/L (nominal conc.)

Details on test conditions:

Growth was monitored daily by determining the cell density of each culture by direct counts using an optical microscope.

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

54.6 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

other: based on Water Accomodated Fractions (WAFs)

Basis for effect:

growth rate

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

14.21 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

other: based on Water Accomodated Fractions (WAFs)

Basis for effect:

growth rate

Validity criteria fulfilled:

yes

Key value for chemical safety assessment

EC50 for freshwater algae:

54.6 mg/L

EC10 or NOEC for freshwater algae:

14.21 mg/L