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EC number: 947-964-7
CAS number: -
Table 1: OD values and viability percentages of the controls:
Optical Density (OD)
Negative Control:NaCl (9 g/L saline)
Positive Control:Glacial acetic acid
Table 2: OD
values and viability percentages of the test item (including corrected
study was conducted to determine the skin corrosion potential of the
test item. Disks of EPISKIN (two units) were treated with the test item
and incubated for 4 hours (±10 min) at room temperature. Exposure of the
test material was terminated by rinsing with PBS 1x solution. The
viability of each disk was assessed by incubating the tissues for 3
hours (±15 min) with 5±1 % CO2 in a ≥ 95% humidified atmosphere and
protected from light. The formazan precipitated was then extracted using
acidified isopropanol and quantified spectrophotometrically. NaCl (9 g/L
saline) and glacial acetic acid treated epidermis were used as negative
and positive controls, respectively. The test item did not show
significantly reduced cell viability in comparison to the negative
control after four hours of exposure. Both individual tissue viabilities
were above 35 % of the mean negative control value. The average test
item treated tissue viability was 103 %. Positive and negative controls
showed the expected cell viability values within acceptable limits. The
experiment was considered to be valid. The results obtained from this in
vitro skin corrosion test, using the EPISKIN model, indicated that the
test item reveals no skin corrosion potential. This result can be used
together with further information on the irritative nature of the
substance to decide on its final classification.
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