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EC number: 947-964-7
CAS number: -
Oral LD50 >= 5000 mg/kg bw in rats.Dermal LD50 > 5000 mg/kg bw in rats.
acute oral toxicity study was carried out using the class method
according to OECD guideline 423. The method was conducted using a
stepwise procedure with 2000 mg/kg bw as the starting dose in three
female rats. No animal died in the first step at 2000 mg/kg bw dose
level, so further three female rats were treated with the same (2000
mg/kg bw) dose. No animal died in the second step, so the test was
finished, as a stopping criterion of Annex 2d of OECD Guideline No. 423
(presented in Appendix 7) was met. All animals were weighed, observed
for lethality and toxic symptoms for 14 days after the treatment. Gross
pathological examination was carried out on the 15th day after the
treatment. No mortality and no test item related adverse effects
regarding body weight development or clinical observations were
revealed. Therefore test item is not to be classified according to the
GHS classification and the median lethal dose derived was: LD50 cut off
≥ 5000 mg/kg bw.
An acute oral toxicity study according to
the acute toxic class method was performed revealing an LD50 value of ≥
5000 mg/kg bw.
In accordance with column 2 of REACH Annex VIII, the study does not need
to be conducted as the substance does not meet the criteria for
classification for acute oral toxicity, i. e. the acute oral LD50 value
is > 5000 mg/kg bw.
Labelling, and Packaging Regulation (EC) No 1272/2008
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. Based on the
available oral and dermal LD50
values in rats the test item is not classified according to
Regulation (EC) No 1272/2008
amended for the twelfth time in Regulation (EU) No 2019/521.
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