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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Method: other: BASF test
GLP compliance:
no
Test type:
other: inhalation risk test (IRT)
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-2,3-diol
EC Number:
208-173-6
EC Name:
Butane-2,3-diol
Cas Number:
513-85-9
Molecular formula:
C4H10O2
IUPAC Name:
butane-2,3-diol
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
saturated atmosphere (20°C); max 0.85 mg/l
No. of animals per sex per dose:
a total of 12 animals
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.85 mg/L air
Based on:
other: saturated atmosphere of the test item

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:
No mortality was observed when 12 rats were exposed for 7 h to an atmosphere that has been saturated at 20°C with the volatile part of the compound.