Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report Date:
2019

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
13 April 2004
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Test material form:
solid: crystalline

Study design

Analytical method:
liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
ca. 2.7
Key result
Type:
log Pow
Partition coefficient:
< 0.3
Temp.:
25 °C
pH:
ca. 8.8

Applicant's summary and conclusion

Conclusions:
In the course of this study the partition coefficient (Pow) of Ammonium Adipate was
determined using high performance liquid chromatography.
Retention times measured for Ammonium Adipate (1.64 min (Method 1), 2.34 min (Method
2) and 1.50 min (Method 3)) are lower than the retention time of the first eluting standard;
2-Butanone (3.76 min (Method 1), 3.74 (Method 2) and 3.82 min (Method 3)). This result
shows that log Pow of Ammonium Adipate is lower than the calibrated range.
Using the HPLC method the log Pow of Ammonium Adipate was determined to be < 0.3.
Executive summary:

In the course of this study the partition coefficient (Pow) of Ammonium Adipate was
determined using high performance liquid chromatography.
Retention times measured for Ammonium Adipate (1.64 min (Method 1), 2.34 min (Method
2) and 1.50 min (Method 3)) are lower than the retention time of the first eluting standard;
2-Butanone (3.76 min (Method 1), 3.74 (Method 2) and 3.82 min (Method 3)). This result
shows that log P
owof Ammonium Adipate is lower than the calibrated range.
Using the HPLC method the log P
owof Ammonium Adipate was determined to be < 0.3.