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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Nov. 2017 - Jan. 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted 23. Mar. 2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell
Temp.:
20 °C
Vapour pressure:
0.004 Pa
Temp.:
25 °C
Vapour pressure:
0.004 Pa
 T  T  p  Standard Deviation p  RSD p
 °C  K  Pa  Pa  %
 105.0  378.2  2.26E-02  6.35E-03  28.1
 120.0  393.2  2.86E-02  6.98E-03  24.4
 135.0  408.2  3.77E-02  5.58E-03  14.8
 150.0  423.2  4.22E-02  6.81E-03  16.2
Conclusions:
Vapour pressure at 20°C: 3.89E-03 Pa
Vapour pressure at 25°C: 4.44E-03 Pa
Executive summary:

The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 under GLP conditions using the effusion method (weight loss). Experiment 1-5 (nominal temperature 30 - 90°C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.

Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 29 % (limit value from the guideline 30 %) and good correlation.

Therefore, the result of the test can be considered valid. As result it was received, that the vapour pressure is 0.00389 Pa at 20 °C and 0.00444 Pa at 25 °C.

Description of key information

The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 under GLP conditions using the effusion method (weight loss). Experiment 1-5 (nominal temperature 30 - 90°C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.

Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 29 % (limit value from the guideline 30 %) and good correlation.

Therefore, the result of the test can be considered valid. As result it was received, that the vapour pressure is 0.00389 Pa at 20 °C and 0.00444 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:
0.004 Pa
at the temperature of:
20 °C

Additional information