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EC number: 701-200-7
CAS number: -
In a GLP-compliant OECD Guideline 406 study,
skin sensitisation properties of multiconstituent aluminium potassium
fluoride were studied in guinea pig.
Test substance concentrations selected for
the main study were based on the results of a preliminary study. In the
main study, ten experimental animals were intradermally injected with a
2% concentration and epidermally exposed to a 50% concentration. Five
control animals were similarly treated, but with the vehicle (1% aqueous
carboxymethyl cellulose) only. Approximately 24 hours before the
epidermal induction exposure all animals were treated with 10% SDS. Two
weeks after epidermal application all animals were challenged with a 50%
test substance concentration an the vehicle.
No evidence was obtained that the test
substance had caused skin hypersensitivity in the guinea pig, since no
responses were observed in the experimental animals in the challenge
phase. This result indicates a sensitization rate of 0 per cent.
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