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EC number: 701-200-7
CAS number: -
acute eye irritation/corrosion of multiconstituent
aluminium potassium fluoride in
the rabbit was investigated in a non-guideline study. Despite some
restrictions in design and/or reporting, the study is considered as
adequate for assessment. A
single sample 0.07 g (0.1 ml weight equivalent) of the finely ground
test material was placed on the lower lid of one eye of three male and
three female rabbits. The other eye served as the untreated control. The
treated eyes were observed for ocular irritation at 24, 48, 72 and 96
hours and at 7 days after treatment. Because injury was present at 7
days, observations were continued at 14 and 21 days.
White necrotic areas
on the conjunctivae were seen in two animals at 24, 48, 72 and 96 hours
and 7 days. Pannus was observed in two animals at 7, 14 and 21 days. One
animal exhibited corneal neovascularization at day 21. Based on the eye
irritation scores, it is concluded that the multiconstituent
aluminium potassium fluoride is irritating to eyes.
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