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EC number: 701-200-7
CAS number: -
The acute inhalation toxicity of
multiconsituent aluminium potassium fluoride in the rat was investigated
in a GLP compliant, non-guideline study. Despite some minor restrictions
in design and/or reporting, the study is considered as adequate for
One group of 5 male and 5 female rats was
exposed whole body to a dust atmosphere of the test substance. The
duration of the exposure was 1 hour followed by a 14 day observation
period. The gravimetric concentration of test article in the test
atmosphere was 4.92 mg/l. Particle size analysis of the exposure chamber
revealed a mass median diameter of 1.30 µm and geometric standard
deviation of 1.58.
Four of the test animals died during the
study. Irregular breathing, poor coat quality, yellow/brown stained fur,
lethargy, crusty eye, crusty nose, and crusty muzzle were observed among
the test animals during the study period. Necropsies revealed no gross
lesions in 5 of 10 test animals. Abnormalities of the small intestine,
stomach, and heart were observed in the remaining test rats. Based on
the observed mortality it can be concluded that the 1-hour LC40 of the
test substance is 4.92 mg/L which would correspond to a 4-hour LC40 of
1.23 mg/l when applying Haber's rule. The 4 -hour LC50 will be slightly
above this concentration.
on the above observations, the inhalatory LC50, 4h value of
multconstituent aluminium potassium fluoride in rats was established to
be within the range of 1 – 5 mg/L and therefore the test
to be classified as Category 4 H332 'Harmful if inhaled' according to
Classification, Labelling and Packaging of Substances and Mixtures (CLP)
Regulation (EC) No. 1272/2008.
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