Zirconium hydroxysulphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

In-house data assessment.
Solublity assessed at different pH and assessed in hardened water

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

Solubility at range of pH was investigated as has relevance for environmental and toxicological assessments.
Solublity in hardend water at low concentrations was also assessed for environmental relevance

GLP compliance:

no

Type of method:

flask method

Specific details on test material used for the study:

Batch No : D-02-4057

Key result

Water solubility:

> 500 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 1.9

Remarks on result:

completely miscible

Remarks:

pH unadjusted

Water solubility:

> 20 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

20 °C

pH:

ca. 3

Remarks on result:

other: pH buffered for evaluation of solubility at different pH

Water solubility:

< 1 g/L

Conc. based on:

test mat. (total fraction)

Temp.:

20 °C

pH:

ca. 4

Remarks on result:

other: Buffered to pH 4

Water solubility:

< 100 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

100 mg/L

Temp.:

20 °C

pH:

ca. 3

Remarks on result:

other: Environmental hardness ca 100 mg/l caCO3

Water solubility:

ca. 1 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 mg/L

Temp.:

20 °C

pH:

4.3

Remarks on result:

other: Evironmental hardness ca 100 mg CaCO3

Details on results:

The data indicate reduced solubility in water when buffered to > pH 3
When repeated in hardened water, but no buffer, solublity was ca 1 mg/l based on test material, with a pH of 4.3 recorded.
A loading of 20 g/l in distilled water, buffered to pH 3 was soluble, but when 1 g/l was in hardened water, it was insoluble at pH 3

Conclusions:

The solubility is pH dependant with reduced solublity at pH 4 or more, suggesting formation of hydroxide / oxide
The substance supplied is typically in acidic solution
The data indicate reduced solubility in water when buffered to > pH 3
When repeated in hardened water, but no buffer, solublity was ca 1 mg/l based on test material, with a pH of 4.3 recorded.
A loading of 20 g/l in distilled water, buffered to pH 3 was soluble, but when 1 g/l was in hardened water, it was insoluble at pH 3