Registration Dossier
Registration Dossier
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EC number: 204-612-0 | CAS number: 123-25-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance Raw Materials Monographs - Diethyl Succinate
- Author:
- Anon.
- Year:
- 1 978
- Bibliographic source:
- Food Cosmet. Toxicol. 16 (Suppl.1): 707, 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No more details available, database match.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethyl succinate
- EC Number:
- 204-612-0
- EC Name:
- Diethyl succinate
- Cas Number:
- 123-25-1
- Molecular formula:
- C8H14O4
- IUPAC Name:
- 1,4-diethyl butanedioate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 5 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.
- Executive summary:
Median lethal dose (LD50) in the rabbit following demal administration is reported to be in excess of 5000 mg/kg bw.
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