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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted on 27th July 1995
GLP compliance:
not specified
Type of method:
other: Shake Flask Method
Partition coefficient type:
octanol-water
Analytical method:
gas chromatography
Remarks on result:
other: Solubility of sample in water is too small to be detected, and the partition coefficient can’t be calculated.
Details on results:
pH of test water was 6.5, and a Pow value is calculated from the data of each run. Altogether six values are obtained since the test conditions are: three duplicate runs with different solvent ratios, and possibly also different quantities of test substance. The six log POW values should fall within a range of ± 0.3 units. A POW value is calculated from the data of each run. Altogether six values are obtained since the test conditions are: three duplicate runs with different solvent ratios, and possibly also different quantities of test substance. The six log POW values should fall within a range of ± 0.3 units.
pH of six aqueous solution was test to be 3.99,3.97,3.97,4.00,4.00,4.02.
Conclusions:
Solubility of sample in water is too small to be detected, and the partition coefficient can’t be calculated.

Description of key information

The water solubility was determined according to "Shake Flask method" in OECD 107 - Partition Coeffcient(n-0ctanol/water).

Key value for chemical safety assessment

Additional information

Solubility of sample in water is too small to be detected, and the partition coefficient can’t be calculated.