Registration Dossier

Administrative data

Description of key information

Data show slight irritation to the skin and eye, which is fully reversible and below the level of classification.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

The material appears to be a mild primary skin irritant (mean erythema score of 1 at 24 hrs and 0.6 at 48 hrs) when tested as a 10% w/v suspension in mineral spirits. It does not appear to be a fatiguing agent or a sensitizing agent in the albino guinea pig. The effects are reversible and below the level of classification as a skin irritant.

Treatment of the eyes with the neat substance resulted in average ocular irritation scores of 3.3, 2.3, 0.7, 0.0, and 0.0 on days 1, 2, 3, 5 and 7, respectively. The eye irritant was reversible and below the level of classification as an eye irritant.

Justification for classification or non-classification

Slight skin and eye irritant, though irritation scores are well below the level of classification.