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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Other (1981). The method employed in the testing, evaluation, and the scoring of the results was adopted from the U.S. Federal Hazardous Substances Act Regulations study guidelines, 16 CFR, section 1500.3.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Triisodecyl phosphite - Commercial, purity: > 97% (Phosphorus content = 6.17 %)- Lot/batch No.: TDPx-003-04070A- Supplier: Borg Warner Company, Parkersburg, WV

Test animals

Species:
rat
Strain:
other: Sherman/Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS- Weight at study initiation: 200 and 300 grams - Fasting period before study: fasted overnight, but were not deprived of water. - Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3. - Diet (e.g. ad libitum): Following administration the animals were allowed food ad libitum - Water (e.g. ad libitum): Following administration the animals were allowed water ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
The sample was dosed as supplied (described as a colorless to straw-colored liquid).
Doses:
5 g/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 21 days The LD50 was calculated using the method described by Finney, D.J. 1971. ‘Statistical Methods in Biological Assay, 2nd Edition, London Griffen Press.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 other: g/kg
Mortality:
No animals died during the experiment.
Gross pathology:
Gross pathological examination revealed no remarkable findings.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
No signs of acute toxicity at a limit dose of 5 g/kg.
Executive summary:

Not acutely toxic via the oral route at the limit dose of 5 g/kg. Not classified as acutely toxic.