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EC number: 949-147-0
CAS number: 1041263-42-6
Tris 2 -propylheptyl phosphite
(T2PHP) is one of several structurally related tris alkyl phosphites.
Alkyl phosphites are characterized by a phosphorus atom connected to
three alkyl ester groups (oxygen connected to an alkyl chain). The
closest alkyl phosphite structural analog to T2PHP is triisodecyl
phosphite (TDP). Like T2PHP, the alkyl groups on TDP are branched,C10,
isomers. TDP has an existing OECD 422 study. The NOAELs in this
assessment are based on the TDP OECD 422 study (Tyl 2005)
Relationship Between Alkyl
Phosphites and Alkyl Alcohols
These alkyl phosphites are
manufactured using a class of alkyl alcohols that have been well studied
and previously accepted as a category (Long Chain Alcohols Category
under the OECD SIDS program; Alkyl Alcohols C6 to C13 Category under the
U. S. High Production Volume (HPV) program). The category assessment and
associated use of read-across data for these alkyl alcohols is
particularly relevant for the alkyl phosphites because these phosphites
readily hydrolyze into the associated alcohol used in the manufacture of
the phosphite – TDP to isodecanol (C10) and T2PHP to 2 -propylheptanol
(C10). Given this, it appears appropriate to consider both the category
approach that was used to assess the alkyl alcohols under REACH as well
as the data on the relevant alcohols as analogs to T2PHP and the related
There were no signs of acute
toxicity by either the oral, inhalation or dermal routes. As such, it is
not necessary or appropriate to establish acute DNELs.
Dermal Local DNELs
TDP test positive in an LLNA
skin sensitisation study. The EC3 concentration was 20%. The DNEL has
derived as follows:
DNEL = EC3[%] * 250 [µg/cm²/%] /
AF = 20% * 250 µg/cm²/% / 30 = 166.7 µg/cm²
Long-Term Systemic DNELs
The basis for the long-term
systemic DNELs is the NOAEL of 1000 mg/kg/day (top dose) from the Tyl
(2005) oral gavage combined repeat-dose and reproductive/developmental
study in rats. The inhalation and
dermal DNELs were extrapolated from the oral study using standard
route-to-route extrapolations and assuming 50% oral and inhalation
absorption and 10% dermal absorption.
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