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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 July 2017 - 27 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl ethoxymethylenemalonate
EC Number:
201-725-7
EC Name:
Diethyl ethoxymethylenemalonate
Cas Number:
87-13-8
Molecular formula:
C10H16O5
IUPAC Name:
diethyl ethoxymethylenemalonate
Test material form:
liquid
Specific details on test material used for the study:
- Batch n°: JC170405
- Analytical purity: 99.5%
- Expiration date: 12 April 2018
- Storage condition: at room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
< -80 °C
Atm. press.:
1 011 hPa
Decomposition:
no

Any other information on results incl. tables

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly at 225°C. At 273°C the sample weight has decreased by 25%. After the experiment, no test item was observed in the sample container.

Main study

- Experiment 1: During cooling no effects were observed. During heating an endothermic peak between 200°C and 300°C was observed. The extrapolated onset temperature of the peak was 283.279°C. The effect was most likely obtained due to evaporation of the test item. After the experiment it was observed that the test item was evaporated from the sample container.

- Experiment 2 was performed to determine the duplicate melting temperature of the test item. Similar results as with Experiment 1 were obtained. The extrapolated onset of the evaporation peak was 270.150°C. After the experiment it was observed that the test item was evaporated from the sample container.

- Experiment 3 was performed to determine the duplicate melting temperature of the test item. Similar results as with Experiment 1 were obtained. The extrapolated onset of the boiling peak was 282.657°C. After the experiment it was observed that the test item was evaporated from the sample container.

- Support that boiling caused the endothermic peak, a higher heating rate of 50°C/minute was applied in Experiment 4. The extrapolated onset temperature of the evaporation peak was 285.290°C. The similar value obtained demonstrated that boiling of the test item was the reason for the endothermic effect. After the experiment it was observed that the test item was evaporated from the sample container.

- To further investigate the melting temperature of the test item, two subsamples of the test item were stored for 24 hours at -19.3 ± 0.4°C and at -79.9 ± 1.3°C respectively. It was observed after storage that the test item was a liquid (-20°C freezer) and a viscous liquid (-80°C freezer). According to this it was concluded that the melting temperature of the test item is < -80°C (< 193K).

Applicant's summary and conclusion

Conclusions:
The melting temperature of JNJ-39005525-AAA (EMME) was determined at < -80°C (< 193K) by applying a storage experiment in the freezer.