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EC number: 201-487-4
CAS number: 83-56-7
of acute oral toxicity with naphthalene-1,5-diol
in the rat (Acute Toxic Class Method). The study was carried out based
on the guidelines described in: "Acute Toxicity-Oral, Acute Toxic Class
Method", OECD No.423 (2001); "Acute Oral Toxicity"; EC Commission
Directive 96/54/EC, Part 8.1 tris (1996); Environmental Protection
Agency (EPA): Health Effects Test Guidelines OPPTS 870.1100 (2002),
"Acute Oral Toxicity - Acute Toxic Class Method" and JMAFF Japanese test
substance was administered by oral gavage to three Wistar rats of each
sex at 2000 mg/kg body weight. Animals were subjected to daily
observations and weekly determination of body weight.
macroscopic post mortem examination of the animals.
of naphthalene-1,5 -diol in Wistar rats was established to exceed 2000
mg/kg body weight.
to the OECD 423 test guideline the LD50 cut-off value was considered to
exceed 5000 mg/kg body weight.
on these results naphthalene-1,5 -diol does not have to be classified
and has no obligatory labelling requirement for oral toxicity according
to the OECD Harmonized Integrated Hazard Classification System for Human
Health and Environmental Effects of Chemical Substances (OECD, 1998) and
EC criteria for classification and labelling requirements for dangerous
substances and preparations (Council Directive 67/548/EEC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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