Registration Dossier
Registration Dossier
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EC number: 257-765-0 | CAS number: 52234-82-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Reliable predicted value obtained by the OECD QSAR Toolbox using trend analysis within category members.The prediction fulfilling the OECD criteria for the validation of QSAR models with respect to • a defined endpoint • unambiguous algorithm • a defined domain of applicability • appropriate measure of goodness-of-fit, robustness and predictivity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Principles of method if other than guideline:
- Calculation using QSAR Toolbox based on trend analysis within category members.
Test material
- Reference substance name:
- 2-[(3-aziridin-1-ylpropionyl)methyl]-2-ethylpropane-1,3-diyl bis(aziridine-1-propionate)
- EC Number:
- 257-765-0
- EC Name:
- 2-[(3-aziridin-1-ylpropionyl)methyl]-2-ethylpropane-1,3-diyl bis(aziridine-1-propionate)
- Cas Number:
- 52234-82-9
- Molecular formula:
- C21H35N3O6
- IUPAC Name:
- 6-(aziridin-1-yl)-2-({[3-(aziridin-1-yl)propanoyl]oxy}methyl)-2-ethyl-4-oxohexyl 3-(aziridin-1-yl)propanoate
1
Test organisms
- Test organisms (species):
- other: Desmodesmus subspicatus, Desmodesmus subspicatus (reported as Scenedesmus subspicatus), Pseudokirchnerella subcapitata, Scenedesmus subspicatus (new name: Desmodesmus subspicatus), Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata)
Study design
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 784 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 375 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
