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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1992
Report date:
1957
Reference Type:
other: The EFSA Journal
Title:
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20
Author:
EFSA
Year:
2007
Bibliographic source:
QUESTION N° EFSA-Q-2003-163
Report date:
2005

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-hydroxybenzaldehyde
EC Number:
204-599-1
EC Name:
4-hydroxybenzaldehyde
Cas Number:
123-08-0
Molecular formula:
C7H6O2
IUPAC Name:
4-hydroxybenzaldehyde
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20 % suspension in vehicle
Doses:
500, 2000 and 3980 mg/kg bw
No. of animals per sex per dose:
2
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 980 mg/kg bw
Based on:
test mat.
Mortality:
at the dose of 3980 mg/kg bw 1/2 animals died.
Clinical signs:
500 mg/kg bw: Animals became drowsy shortly after administration.
2000 mg/kg bw: Animals developed tremors shortly following administration.
3980 mg/kg bw: Animals developed tremors shortly following administration.

Some bilateral hydronephrosis was observed on doses of 500 mg/kg bw and greater.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 was 3980 mg/kg bw in rats.