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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-09-13 to 2018-01-31
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
Version / remarks:
January 21, 1998
Deviations:
no
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
mass based distribution
Remarks on result:
not measured/tested
Key result
Percentile:
D10
Mean:
8.1 µm
Remarks on result:
other: Standard deviation was not determined.
Key result
Percentile:
D50
Mean:
22.4 µm
Remarks on result:
other: Standard deviation was not determined
Key result
Percentile:
D90
Mean:
37.3 µm
Remarks on result:
other: Standard deviation was not determined
Conclusions:
The test item Tetrahydrofolic acid has a median particle size D50 = 22 µm, which was determined by laser diffraction measurement, according to ISO 13320 and OECD 110.

Description of key information

Particle size distribution: D50 = 22.4 µm (OECD 110, GLP)

Additional information

The test item Tetrahydrofolic acid has a median particle size D50 = 22 µm, which was determined by laser diffraction measurement, according to ISO 13320 and OECD 110.