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EC number: 205-181-1
CAS number: 135-16-0
A preliminary thermogravimetric measurement
was performed over a temperature range from room temperature to approx.
Three steps were registered with maxima at
125 °C, 239 °C resp. 309 °C. A total mass loss of 57.1 % at the final
temperature could be observed (mass change in the range until 205 °C:
4.6 %; mass change in the range from 205 to 600 °C: 51.5%). Mass loss
due to purging: 1.0 %. After cooling the residue was grey-black-shiny
frothed coming out of the lid.
The DSC measurements were performed twice:
the first one in the temperature range from 0 - 350 °C, which was
cancelled at approx. 240 °C. The second run was performed in the range
from 0 - 200 °C.
An endothermic peak indicating a melting
point could be observed (peak maximum: 189 °C/189 °C: extrapolated onset
temperature: 180.85 °C/ 180.89 °C; rounded mean of both determinations:
181 °C). The shape of this peak did not show the typical sharp, slim
Reweighing after the measurement showed that
the sample had lost 9.4 %/ 5.1 % of its mass. The mass loss may be due
to release of moisture or crystal water. It corresponds to the mass loss
during the thermogravimetric measurement. After the first run the
residue looked black frothed coming out of the lid; after the second run
the residue looked like a solidified melt, shiny and dark-discoloured.
Melting point: 181°C at 1013 hPa (OECD 102,
Tetrahydrofolic acid has a melting point of
181°C at 1013 hPa as determined in a study conducted according to OECD
TG 102 (1995), GLP, by differential scanning calorimetry.
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