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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Remarks:
ultrapure water
Details on test solutions:
a special solubilization protocol was carried out before the experimentation according to OECD n°23 guidance document on aquatic toxicity testing of difficult subtances and mixtures

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
other: ultrapure water
Limit test:
no
Total exposure duration:
48 h

Test conditions

Test temperature:
between 18 and 22°C
pH:
range 6 - 9
Nominal and measured concentrations:
0.6 - 1.2 - 2.5 - 5 - 10 and 20 mg/L
Reference substance (positive control):
yes
Remarks:
K2Cr2O7

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
11.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
5.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Results with reference substance (positive control):
not precised

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The results obtained for Stiripentol Stade 1 are :
- EC50-24h = 11.3 mg/L
- EC50-48h = 5.4 mg/L
In regard to these results the test item can be classified in Category : Acute II.
Executive summary:

The acute toxicity on aquatic invertebrates was performed according the OECD 202 guideline.

The results obtained for Stiripentol Stade 1 are :

-  EC50-24h = 11.3 mg/L

- EC50-48h = 5.4 mg/L

In regard to these results the test item can be classified in Category : Acute II.