Registration Dossier
Registration Dossier
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EC number: 253-021-4 | CAS number: 36411-52-6
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 2017- 01 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ of 2002
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- EC Number:
- 253-021-4
- EC Name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- Cas Number:
- 36411-52-6
- Molecular formula:
- C9H8N4O2
- IUPAC Name:
- 2-hydroxy-N-1H-1,2,4-triazol-3-ylbenzamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch:102Z5
Purity: 99.9%
white powder
Constituent 1
Results and discussion
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- ca. 96.3 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- ca. 1.07 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- ca. 0.101 %
Applicant's summary and conclusion
- Conclusions:
- Particle size data acquired for the test item:
Percentage of test item with an inhalable particle size <100 μm, (Method: Sieve), 96.3%
Percentage of test item with a thoracic particle size <10.0 μm, (Method: Cascade Impactor), 1.07%
Percentage of test item with a respirable particle size <5.5 μm, (Method: Cascade Impactor), 0.101%
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