1,2-Ethanediamine, N-{3-(trimethoxysilyl)propyl}-,N-{(ethenylphenyl)methyl}derivate,hydrochlorides

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

75 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Description of key information

LC50 (96 h) = 75 mg/L (nominal, OECD 203) based on read across from reaction mass containing six benzylated amine silanes (EC 700 -961 -2).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

75 mg/L

Additional information

Experimental data on the toxicity of 1,2-Ethanediamine, N-{3-(trimethoxysilyl)propyl}-,N-{(ethenylphenyl)methyl}derivate,hydrochlorides (CAS 171869-89-9) towards freshwater fish are not available. Therefore, in accordance with the Regulation (EC) No. 1907/2006 Annex XI, 1.5 “Grouping of substances and read across” and the read across assessment framework (RAAF, ECHA 2017) a read across from the analogue substance reaction mass containing six benzylated amine silanes (EC 700 -961 -2) has been performed. Details on the read-across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.

In an acute fish toxicity test (1993) according to OECD 203, Cyprinus carpio was exposed to 5 nominal concentrations of 10, 18, 32, 56 and 100 mg/L of reaction mass containing six benzylated amine silanes. The test item is a complex substance, which degrades quickly in water into monomeric (benzyl substituted aminoalkylsilane triols) or oligomeric (di-, tri-, or higher benzyl substituted aminoalkylsiloxanes) silicon-based substances and methanol. The test was performed with the parent substance, which is supposed to display the principal aquatic hazard. However, the assessment of the toxic potential of exposure of fish to the reaction mass of six benzylated aminesilanes was conducted in a static system, in order to additionally include exposure of the tested organisms to the hydrolysis products. Due to the rapid hydrolysis of the parent substance it is assumed that the test organisms were predominantly exposed to the degradation products. The study resulted into an LC50 (96 h) of 75 mg/L (nominal).

Based on the results of the analogue substance and as justified in the attached justification in the target IUCLID entry, similar results are expected with the target substance 1,2-Ethanediamine, N-{3-(trimethoxysilyl)propyl}-, N-{(ethenylphenyl)methyl}derivate, hydrochlorides (CAS 171869-89-9).