Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 411-150-5 | CAS number: 29617-66-1 L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
Endpoint summary
Administrative data
Description of key information
Annex VII of Regulation (EC) No 1907/2006, sections 8.1 and 8.2 state that studies for skin irritation/corrosion and eye irritation do not need to be conducted if ‘the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes’.
L-2-Chloropropionic acid is classified under the CLP Regulation EC 1272/2008 Annex VI as Skin Corr. 1A (H314: causes severe skin burns and eye damage).
Available data confirm the corrosivity of the substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There are no skin irritation/corrosion or eye irritation studies available on L-2-Chloropropionic acid.
Annex VII of Regulation (EC) No 1907/2006, sections 8.1 and 8.2 state that studies for skin irritation/corrosion and eye irritation do not need to be conducted if ‘the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes’.
A study to measure the pH on a 1% vol aqueous solution of L-2-chlorpropionic acid gave a pH of 1.83, showing that the test substance is highly acidic and likely to be corrosive.
Data has been reported on 2-chloropropionic acid, the racemic form of the substance, by the American Conference of Governmental Industrial Hygienists, which states that based on human data the substance is considered ‘corrosive to the eye and skin’.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
L-2-Chloropropionic acid is classified under the CLP Regulation EC 1272/2008 Annex VI as Skin Corr. 1A (H314: causes severe skin burns and eye damage).
It is concluded that no study is required and that existing available information is sufficient to corroborate the Skin Corr. 1A classification listed on EC 1272/2008 Annex VI.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
