Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-531-3 | CAS number: 142-28-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- information derived from published data
- Type of information:
- other: information derived from published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- GESTIS Substance Database 1,3-Dichloropropane
- Author:
- IFA Institue for Occupational Safety and Health of the German Social Accident Insurance
- Year:
- 2 018
- Bibliographic source:
- http://gestis-en.itrust.de/pdf/create/Data_sheet.php
Materials and methods
- Principles of method if other than guideline:
- observation by professionals, including Biomonitoring and adminstrative measures
- GLP compliance:
- not specified
- Remarks:
- assumed to be GLP
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- no data available
Test animals / tissue source
- Species:
- other: Homo sapiens
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- cohort is professional workers
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- irregular, max. 10 h/d
- Number of animals or in vitro replicates:
- cohort is small because no full registration in EU so far
Results and discussion
In vitro
Results
- Irritation parameter:
- other: irritation by exposure of eyes to workplace air
- Run / experiment:
- daily work, assumed to be 8 h per 5d week and 48 w/year
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- no measured workplace concentrations available
In vivo
- Irritant / corrosive response data:
- GESTIS: "Manufacturers indicate that the liquid triggers moderate irritations to the eyes, but does not cause any severe or persistent damage."
Applicant's summary and conclusion
- Interpretation of results:
- other: data cannot be used for classification and the classification of the GESTIS is followed
- Conclusions:
- "Manufacturers indicate that the liquid triggers moderate irritations to the eyes, but does not cause any severe or persistent damage."
The classification reported in GESTIS is: Eye irritation, Category 2; H319 Causes serious eye irritation. - Executive summary:
Eye irritation, Category 2; H319
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
