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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 January 2018 to 7 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
11 July 2006
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
Test Item
Appearance: Clear light amber liquid
Purity/Composition: >90%
Test item storage: At room temperature


Additional information
Test Facility test item number: 209077/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Molecular structure: Not indicated
Molecular formula: C63H110O12
Molecular weight: 1059

Test Item Characterization
The Sponsor provided to the Test Facility documentation of the identity, purity, composition, and stability for the test item(s). A Certificate of Analysis or equivalent document was provided to the Test Facility and is presented in Appendix 2.
Key result
Test no.:
#1
Temp.:
ca. 20 °C
Vapour pressure:
< 0 Pa
Key result
Test no.:
#2
Temp.:
ca. 25 °C
Vapour pressure:
< 0 Pa

A representative weight loss curve of the test item isshown in Figure 4. The results are given in Table 3.

During both measurements no significant weight lost was observed. A log pversus1/T curve for the test itemin the range of 200°C and 230°C could not be determined.The coefficient of correlation (r) was < 0.99 (data is archived in the raw data).

The weight losses were compared with the results of benzo[ghi]peryleneat the same temperatures. Theweight loss curve of this reference substance is shown in Figure 5.

Table 3          
Results of the Vapour pressure Isothermal TGA Analysis

Temperature
[°C]

Weight loss
[µg/min]

νT
[g/cm2/h]

logνT

logPT

PT
[Pa]

200

0.302941

3.62´10-5

-4.44

-0.55

0.28

 

0.275136

3.28´10-5

-4.48

-0.60

0.25

210

0.375625

4.48´10-5

-4.35

-0.43

0.37

 

0.363072

4.33´10-5

-4.36

-0.45

0.36

220

0.459085

5.48´10-5

-4.26

-0.32

0.48

 

0.455906

5.44´10-5

-4.26

-0.32

0.48

230

0.611753

7.30´10-5

-4.14

-0.16

0.70

 

0.649171

7.75´10-5

-4.11

-0.12

0.75

Table 4          
Vapour pressure of the Test Item

 

20°C

25°C

 

[Pa]

[mm Hg]

[Pa]

[mm Hg]

Test item

< 1.3´10-8

< 1.0´10-10

< 7.2´10-8

< 5.4´10-10

Conclusions:
The isothermal TGA effusion method was applied for the determination of the vapour pressure of Dermol GTR.
The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:
20°C 25°C
[Pa] [mm Hg] [Pa] [mm Hg]
Test item < 1.3E10-8 < 1.0E10-10 < 7.2E10-8 < 5.4E10-10
No significant weight loss of the test item was observed below the melting temperature of the test item (i.e. a relatively low vapour pressure was obtained).
Executive summary:

In this guideline (OECD 104) study, conducted with GLP certification, the isothermal TGA effusion method was applied for the determination of the vapour pressure of Dermol GTR.

The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:

  20°C 25°C
[Pa] [mm Hg] [Pa] [mm Hg]
Test item < 1.3 ´ 10-8 < 1.0 ´ 10-10 < 7.2 ´ 10-8 < 5.4 ´ 10-10

No significant weight loss of the test item was observed below the melting temperature of the test item (i.e. a relatively low vapour pressure was obtained).

Description of key information

Study performed to recognised study guidelines with GLP certification.

Key value for chemical safety assessment

Additional information

  20°C 25°C
[Pa] [mm Hg] [Pa] [mm Hg]
Test item < 1.3 ´ 10-8 < 1.0 ´ 10-10 < 7.2 ´ 10-8 < 5.4 ´ 10-10