Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

There was also no indication that the related substance tri (hexyl, octyl, decyl) ester was toxic in male or female rats after repeated oral exposure (28 d) up to 1000 mg/kg bw/d. In accordance with column 8 of REACh Annex VIII it is enough to examine one route of application, the most important for human beings. This intrinsic property/toxicity potential can be extrapolated to repeated inhalative route administration.