Registration Dossier
Registration Dossier
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EC number: 205-027-3 | CAS number: 131-54-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Remarks:
- information taken from peer-reviewed literature
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- peer-reviewed literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Addendum to the Final Report on the Safety Assessment of Benzophenones-1, -3, -4, -5, -9, and -11 to Include Benzophenones-2, -6, and -8
- Author:
- Cosmetic Ingredient Review (CIR) Expert Panel
- Year:
- 1 983
- Bibliographic source:
- JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY, Volume 2, Number 5, 1983, Mary Ann Liebert, Inc., Publishers
Materials and methods
Test guideline
- Guideline:
- other: SCE in bone marrow in vivo
- Version / remarks:
- no further details stated
- GLP compliance:
- no
- Type of assay:
- mammalian bone marrow chromosome aberration test
Test material
- Reference substance name:
- 2,2'-dihydroxy-4,4'-dimethoxybenzophenone
- EC Number:
- 205-027-3
- EC Name:
- 2,2'-dihydroxy-4,4'-dimethoxybenzophenone
- Cas Number:
- 131-54-4
- Molecular formula:
- C15H14O5
- IUPAC Name:
- 2-(2-hydroxy-4-methoxybenzoyl)-5-methoxyphenol
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- - Vehicle(s)/solvent(s) used: 10% aqueous acacia solution
Doses / concentrationsopen allclose all
- Dose / conc.:
- 62.5 mg/kg bw/day
- Remarks:
- Hamsters were orally administered 62.5-500 mg/kg Benzophenone-6; no details on intermediate doses are given.
- Dose / conc.:
- 500 mg/kg bw/day
- Remarks:
- Hamsters were orally administered 62.5-500 mg/kg Benzophenone-6; no details on intermediate doses are given.
Examinations
- Tissues and cell types examined:
- bone marrow
Results and discussion
Test results
- Key result
- Sex:
- female
- Genotoxicity:
- negative
- Toxicity:
- no effects
Applicant's summary and conclusion
- Conclusions:
- Data was taken from a peer-reviewed collection of data, so the reults are considered sufficiently reliable to asses the potential of the substance to induce sister chromatid exchanges in vivo. Benzophenone-6 did not induce SCE in vivo in the bone marrow of Chinese hamsters.
- Executive summary:
Female Chinese hamsters were orally administered 62.5-500 mg/kg Benzophenone-6 in a 10% aqueous acacia solution. The animals were sacrificed, and the frequency of bone marrow SCE exchange was determined. Benzophenone-6 did not induce SCE in vivo in the bone marrow of Chinese hamsters. Cytotoxicity was not observed.
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