3,7-dimethylocta-2,6-dienyl acetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January 1972

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

not GLP

Justification for type of information:

This information is used for read-across to Neryl acetate multi

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

no details on test material (purity not indicated), no details on environmental conditions.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Neryl acetate

EC Number:

205-459-2

EC Name:

Neryl acetate

Cas Number:

141-12-8

Molecular formula:

C12H20O2

IUPAC Name:

(2Z)-3,7-dimethylocta-2,6-dien-1-yl acetate

Test animals

Species:

rat

Strain:

other: Charles River strain

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River
- Age at study initiation: Not specified
- Weight at study initiation: 200 to 300 g.
- Fasting period before study: yes, 18 hours
- Housing: housing in raised wire mesh cages in air conditioned room
- Diet: Free acces to Lab Blox
- Water: Free access to tap water.
- Acclimation period: Not specified

ENVIRONMENTAL CONDITIONS
Not specified

Administration / exposure

Route of administration:

oral: gavage

Details on oral exposure:

GAVAGE METHOD: Rigid stomach tube

Frequency: single dosage

MAXIMUM DOSE VOLUME APPLIED:
5 mL/kg body weight.

Doses:

5 mL/kg bw.

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 4 555 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occurred

Clinical signs:

other: No clinical signs were observed.

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

other: Not acutely harmful.

Remarks:

according to EU CLP (EC No. 1272/2008 and its amendments).

Conclusions:

The oral acute LD50 is >4555 mg/kg bw in male and female rats.

Executive summary:

The oral acute toxicity of Neryl Acetate (‘mono’) was investigated in a study comparable to OECD TG 401 (non-GLP). In this study, 5 male and 5 female rats were administered a single oral dose of 5 mL (4555 mg/kg bw based on a relative density of 0.911) by gavage followed by a 14-day observation period. No mortality or other signs of toxicity were observed throughout the test. No clinical signs were noted. Based on these findings, the acute oral LD50 of Neryl Acetate (‘mono’) was determined to be >4555 mg/kg bw.