Registration Dossier
Registration Dossier
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EC number: 252-907-8 | CAS number: 36196-44-8
Endpoint summary
Administrative data
Description of key information
Based on read across from a structurally related category of compounds, TEMPIC is considered to be a strong sensitizer (Skin Sens 1A)
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see attached category justification
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- EC3
- Value:
- > 2
- Test group / Remarks:
- read across
- Remarks on result:
- positive indication of skin sensitisation based on QSAR/QSPR prediction
- Parameter:
- SI
- Value:
- 4.13
- Test group / Remarks:
- 30% CaTG
- Parameter:
- SI
- Value:
- 4.83
- Test group / Remarks:
- 25% KTG
- Parameter:
- SI
- Value:
- 5.89
- Test group / Remarks:
- 25% MeaTG
- Parameter:
- SI
- Value:
- 6.7
- Test group / Remarks:
- 10% NaTG
- Parameter:
- SI
- Value:
- 17
- Test group / Remarks:
- 8% ATG
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
- Conclusions:
- Based on the category hypothesis and the presence of three thiol groups, TEMPIC should be classified as Skin Sens 1A.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the category hypothesis and the presence of three thiol groups, TEMPIC should be classified as Skin Sens 1A.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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