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Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to
Guideline:
OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
Deviations:
not specified
Qualifier:
according to
Guideline:
OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
the test was conducted in an academic setting without GLP certification
Oxygen conditions:
aerobic
Inoculum or test system:
sewage, predominantly domestic, non-adapted
Details on inoculum:
- Source of inoculum/activated sludge: STP of Lüneburg, Germany (144,000 inhabitant
equivalents)
- Initial cell/biomass concentration: two drops of effluent per L
Duration of test (contact time):
28 d
Key result
Parameter:
% degradation (O2 consumption)
Sampling time:
28 d
Remarks on result:
other: please see table below for measured O2 consumption values

Biodegradation test results obtained in the present study. For each experiment the % O2consumption in the two parallel bottles is given, and for valid results the average ±SD, otherwise the criterion rendering a result invalid.

Compound name

(abbreviation)

[CAS-RN]

Experiment number

OECD 301D (CBT)

OECD 301F (MRT)

O2Consumption/

ThOD [%]

Average in a valid experiment ±SD

O2Consumption/ ThOD [%]

Average in a valid experiment ±SD

2*

 

 

18.4, 13.9

16.2 ±3.2

3-MPA and derivatives

3-Mercaptopropionic acid

(3-MPA)

[107-96-0]

1

0.4, 32.4

not valid,

criterion 1

78.7, 87.0

82.8 ±5.9

2

27.4, -7.3

not valid,

criteria 1 and 4

101.4, 90.1

95.8 ±8.0

3

0.6, 3.8

2.2 ±2.3

 

 

Dithiodipropionic acid

(DTDPA, 3-MPA disulfide)

[1119-62-6]

1

3.9, 1.5

2.7 ±1.7

121.6, 87.9

not valid,

criterion 1

2

93.7, 100.3

97.0 ±4.7

Methyl 3-mercaptopropionate

(MMP)

[2935-90-2]

1

65.0, 61.7

63.4 ±2.3

23.3, 12.0

17.7 ±8.0

2

16.0, 21.0

18.5 ±3.6

3

74.1, 14.1

not valid,

criterion 1

4

5.4, 12.3

8.8 ±4.9

Propanoic acid, 3,3'-dithiobis-,

dimethyl ester

(MMP disulfide)

[15441-06-2]

1

6.6, 4.1

5.4 ±1.8

61.6, 84.2

not valid,

criterion 1

2

10.6, 13.0

11.8 ±1.7

14.0, 21.7

17.8 ±5.4

3*

21.6, 1.3

not valid,

criterion 1

Butyl 3-mercaptopropionate

(BuMP)

[16215-21-7]

1

55.6, 29.0

not valid,

criterion 1

15.0, 20.7

17.8 ±4.0

2

57.4, 60.3

not valid,

criterion 4

3

61.9, 62.5

62.2 ±0.5

4

40.8, 41.1

41.0 ±0.2

2-Ethylhexyl 3-mercaptopropionate

(2-EHMP)

[50448-95-8]

1*

54.3, 49.8

52.1 ±3.2

56.4, 27.0

not valid,

criterion 1

2*

42.4, 51.6

47.0 ±6.5

Isooctyl 3-mercaptopropionate
(iOMP)

[30374-01-7]

1**

31.1, 32.1

31.6 ±0.8

-8.2, 4.6

-1.8 ±9.0

Isotridecyl 3-mercaptopropionate

(iC13MP)a

[1040871-35-9]

1**

10.5, 17.6

14.1 ±5.0

29.5, -11.1

not valid,

criterion 1

2**

34.2, 35.8

35.0 ±1.2

Glycol di(3-mercaptopropionate)

(GDMP)

[22504-50-3]

1

2.1, -0.8

0.7 ±2.0

73.4, 39.8

not valid,

criterion 1

2

10.4, 13.6

12.0 ±2.3

32.8, 50.4

41.6 ±12.5

3*

33.4, 41.0

37.2 ±5.3

Trimethylolpropane tris(3-mercapto-propionate)a(TMPMP)

[33007-83-9]

1**

8.2, 9.9

9.1 ±1.2

32.9, 55.4

not valid,

criterion 1

2**

4.7, 1.7

3.2 ±2.1

Dipentaerythrityl hexakis(3-mercaptopropionate)a(DiPETMP)

[25359-71-1]

1**

1.4, 3.3

2.4 ±1.4

14.8, 42.4

not valid,

criterion 1

2**

12.0, -5.5

3.2 ±12.3

Ethoxylated trimethylolpropane tris(3-mercaptopropionate)a

(ETTMP 700)

[674786-83-5 or 345352-19-4]

1**

3.1, -3.2

not valid,

criterion 4

35.1, 40.0

37.6 ±3.5

2**

9.2, 8.6

8.9 ±0.5

amulticonstituent substance (MCS), for details see Experimental

bresult from one test bottle only, the other one became leaky during the experiment

*due to poor solubility, this substance was directly weighed in MRT

**due to very poor solubility, this substance was directly weighed both in CBT and MRT

 

Validity criteria fulfilled:
yes
Interpretation of results:
inherently biodegradable
Remarks:
Based on data with polyvalent sulfyhdyl compounds published in Rücker et al. (2018)..
Conclusions:
The substance TEMPIC is considered to be inherently biodegradable

Description of key information

Based on read-across from related mercaptopropionates, TEMPIC is predicted to be not readily biodegradable. However, the predicted biodegradation exceeds 20% and TEMPIC is thus assumed to be inherently biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
inherently biodegradable
Type of water:
freshwater

Additional information