Registration Dossier
Registration Dossier
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EC number: 443-930-6 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 November 2005 - 11 February 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Batch n°: 00467090 (charge 05C0836)
- Expiration date: 04 May 2006
- Purity: 99.9%
- Storage condition of test material: at room temperature at about 20°C - Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.4
- Temp.:
- 21 °C
- pH:
- >= 4.59 - <= 4.91
- Conclusions:
- The log Pow of T002907 was determined by the flask shaking method to be -0.4.
Reference
| Sample No. | concentration of the test item found | pH of the aqueous phase | Pow | log Pow | |
| n-octanol phase (µg/mL) | aqueous phase* (µg/mL) | ||||
| 1 | 188.23 | 444.04 | 4.66 | 0.424 | -0.37 |
| 2 | 187.09 | 496.07 | 4.59 | 0.377 | -0.42 |
| 3 | 244.61 | 536.03 | 4.75 | 0.456 | -0.34 |
| 4 | 236.87 | 631.17 | 4.73 | 0.375 | -0.43 |
| 5 | 274.94 | 618.10 | 4.91 | 0.445 | -0.35 |
| 6 | 263.36 | 685.62 | 4.90 | 0.384 | -0.42 |
* containing the test item
The mean value Pow (rounded) is 0.410 (standard deviation +/- 0.036) and the log Pow is -0.4 (standard deviation +/- 0.038).
Description of key information
The partition coefficient of T002907 was determined in a GLP study performed according to OECD Guideline 107, EU Method A.8 (Weissenfeld M, 2006).
The shake flask method at pH between 4.59 and 4.91 was applied for the determination of the partition coefficient (Pow). The log Pow of T002907 was -0.4.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.4
- at the temperature of:
- 21 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
