Registration Dossier
Registration Dossier
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EC number: 202-880-3 | CAS number: 100-70-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No method information available
- GLP compliance:
- not specified
- Test type:
- other: unstated test method
Test material
- Reference substance name:
- Pyridine-2-carbonitrile
- EC Number:
- 202-880-3
- EC Name:
- Pyridine-2-carbonitrile
- Cas Number:
- 100-70-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-2-carbonitrile
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Ray Nichols Rabbitry, Lumberton, Texas.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Two female rabbits/dose level were treated with 1000, 750 or 500 mg/kg of test material.
- Duration of exposure:
- not stated
- Doses:
- 1000, 750 or 500 mg/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- not specified
- Statistics:
- not stated
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1000 mg/kg = 2/2
750 mg/kg = 1/2
500 mg/kg = 0/2 - Clinical signs:
- other: Lethargic and slight diarrhea at 1000 and 750 mg/kg dose levels.
- Gross pathology:
- not stated
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Acute dermal LD50 (rabbit, female) = 750 mg/kg
- Executive summary:
Acute dermal LD50 (rabbit, female) = 750 mg/kg
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