Registration Dossier
Registration Dossier
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EC number: 203-484-3 | CAS number: 107-36-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Version / remarks:
- (Q)SAR
- Principles of method if other than guideline:
- Used models:
Prediction and Applicability Domain analysis for models:
Mutagenicity (Ames test) CONSENSUS model 1.0.2
Mutagenicity (Ames test) model (CAESAR) 2.1.13
Mutagenicity (Ames test) model (SarPy/IRFMN) 1.0.7
Mutagenicity (Ames test) model (ISS) 1.0.2
Mutagenicity (Ames test) model (KNN/Read-Across) 1.0.0
Models and repots provided in setion justification (attachemnt) - GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethanesulphonic acid
- EC Number:
- 203-484-3
- EC Name:
- 2-hydroxyethanesulphonic acid
- Cas Number:
- 107-36-8
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- 2-hydroxyethane-1-sulfonic acid
Constituent 1
Results and discussion
Test results
- Key result
- Species / strain:
- other: (Q)SAR
- Metabolic activation:
- not applicable
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- the substance is predicted to be negative in Ames test
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