2,2'-[oxybis(2,1-ethanediyloxy)]bisacetic acid

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-04-04 to 2018-05-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

-29.05 °C

Atm. press.:

1 013.25 hPa

Remarks on result:

other: Glass transition temperature

Preliminaty Test

The test item was frozen in the tubes, therefore, the main test was conducted.

Appearance of the Samples

Before the test the appearance of the test item was colourless, viscous liquid. After the experiments the test item was unchanged in the crucible.

Main Test

Using a linear heating and cooling rate of 0.5 °C/min the freezing point of the test item was determined to be -29.0 °C (244.1 K).

Table 1. Summary of the DSC Tests

Experiment 1	Experiment 2	Experiment 3	Mean	Remark
-28.40	-29.02	-29.73	-29.05 °C	Glass transition temperature

 

Conclusions:

Using a linear heating and cooling rate of 0.5 °C/min the freezing point of the test item was determined to be -29.0 °C (244.1 K).

Executive summary:

A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the freezing point of the test. In order to check the approximate freezing temperature a preliminary test was performed. 1 mL of the test item was transferred into 2 mL cryovials. Four replicate tubes were placed in the freezer. After 24 hours storage period two replicate tubes were removed and the physical state of the test item was examined. The remaining tubes were turned over and immediately put back into the freezer for another 24 hours. Then these tubes were checked if the test item could flow through to the cap of the tube. The test item was frozen in the course of the preliminary test, therefore, the main test with DSC was performed and the freezing point of the test item was determined to be -29 °C.

Description of key information

Using a linear heating and cooling rate of 0.5 °C/min the freezing point of the test item was determined to be -29.0 °C (244.1 K).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-29 °C

Additional information

A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the freezing point of the test. In order to check the approximate freezing temperature a preliminary test was performed. 1 mL of the test item was transferred into 2 mL cryovials. Four replicate tubes were placed in the freezer. After 24 hours storage period two replicate tubes were removed and the physical state of the test item was examined. The remaining tubes were turned over and immediately put back into the freezer for another 24 hours. Then these tubes were checked if the test item could flow through to the cap of the tube. The test item was frozen in the course of the preliminary test, therefore, the main test with DSC was performed and the freezing point of the test item was determined to be -29 °C.